Chitin synthases with a myosin motor - like domain controls the resistance of 1 Aspergillus fumigatus to echinocandins 2 3
نویسندگان
چکیده
Aspergillus fumigatus to echinocandins 2 3 Cristina Jiménez-Ortigosa, Vishukumar Aimanianda, Laetitia Muszkieta, Isabelle 4 Mouyna, David Alsteens, Stéphane Pire, Remi Beau, Sven Krappmann, Anne 5 Beauvais, Yves F. Dufrêne, César Roncero and Jean-Paul Latgé 6 7 Departamento de Microbiología y Genética, Universidad de Salamanca, 37007-Salamanca, 8 Spain; Unité des Aspergillus, Institut Pasteur, 75015 Paris, France; Institute of Condensed 9 Matter and Nanosciences, Université catholique de Louvain, Louvain-la-Neuve, Belgium; 10 Microbiology Institute Clinical Microbiology, Immunology and Hygiene, University 11 Hospital of Erlangen and Friedrich-Alexander-University, Erlangen-Nürnberg, Erlangen, 12 Germany 13 14 Co-corresponding authors 15 *Contributed equally 16 §Present address: Public Health Research Institute, University of Medicine and Dentistry of 17 New Jersey UMDNJ, New Jersey Medical School, 225 Warren St, Newark, NJ 07103, USA 18 19 Copyright © 2012, American Society for Microbiology. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.00752-12 AAC Accepts, published online ahead of print on 10 September 2012
منابع مشابه
Chitin synthases with a myosin motor-like domain control the resistance of Aspergillus fumigatus to echinocandins.
Aspergillus fumigatus has two chitin synthases (CSMA and CSMB) with a myosin motor-like domain (MMD) arranged in a head-to-head configuration. To understand the function of these chitin synthases, single and double csm mutant strains were constructed and analyzed. Although there was a slight reduction in mycelial growth of the mutants, the total chitin synthase activity and the cell wall chitin...
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